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IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
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Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Internal Dataset- Authors
- Catherine RobertsonJamie InshawSuna Onengut-GumuscuWei-Min Chen28 more author(s)...
- Description
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide significant (P < 5 × 10−8) regions, including 36 novel. We define credible sets of T1D-associated variants and show they are enriched in immune cell-accessible chromatin, particularly CD4+ effector T cells. Using chromatin accessibility profiling of CD4+ T cells from...
- Subject
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AllelesChromosome MappingDiabetes Mellitus, Type 1Genetic Predisposition to DiseaseGenetic VariationGenomics
- Access Rights
- Free to All
- Local Expert
- Peter Gregersen
